As Python is increasingly being adopted for large and complex programs, the importance of static analysis for Python (such as type inference) grows. Unfortunately, static analysis for Python remains a challenging task due to its dynamic language features and its abundant external libraries. To help fill this gap, this paper presents PoTo, an Andersen-style context-insensitive and flow-insensitive points-to analysis for Python. PoTo addresses Python-specific challenges and works for large programs via a novel hybrid evaluation, integrating traditional static points-to analysis with concrete evaluation in the Python interpreter for external library calls. We evaluate the analysis with two clients: type inference and call graph construction. The paper presents PoTo+, a static type inference for Python built on the points-to analysis. We evaluate PoTo+ and compare it to two state-of-the-art Python type inference techniques: (1) the static rule-based Pytype and (2) the deep-learning based DLInfer. Our results show that PoTo+ outperforms both Pytype and DLInfer on existing Python packages. We also compare PoTo with PyCG, the state-of-the-art call graph construction analysis for Python, and show that PoTo produces more complete and more precise call graphs.